Name (required) Mail (required) (not be published) Website Make a comment EVENTS & ENTERTAINMENT | FOOD & DRINK | THE ARTS | REAL ESTATE | HOME & GARDEN | WELLNESS | SOCIAL SCENE | GETAWAYS | PARENTS & KIDS Bronson (A459074) is a very affectionate, lovable dog. He is a good side kick, and likes to be only a few paws away at all times. He has been on a few Wiggle Waggle Wagon field trips and volunteers report he is energetic and friendly to people of all ages. He loves going for walks, runs, and is looking for a new best friend. Come visit Bronson at the Pasadena Humane Society today.The adoption fee for dogs is $130. All dogs are spayed or neutered, microchipped, and vaccinated before going to their new home.New adopters will receive a complimentary health-and-wellness exam from VCA Animal Hospitals, as well as a goody bag filled with information about how to care for your pet.View photos of adoptable pets at pasadenahumane.org. Adoption hours are 11 a.m. to 4 p.m. Sunday; 9 a.m. to 5 p.m. Tuesday through Friday; and 9 a.m. to 4 p.m. Saturday.Pets may not be available for adoption and cannot be held for potential adopters by phone calls or email. faithfernandez More » ShareTweetShare on Google+Pin on PinterestSend with WhatsApp,Donald CommunityPCC- COMMUNITYVirtual Schools PasadenaHomes Solve Community/Gov/Pub SafetyPasadena Public WorksPASADENA EVENTS & ACTIVITIES CALENDARClick here for Movie Showtimes Community News First Heatwave Expected Next Week Subscribe Here are the Pets of the Week available for adoption at the Pasadena Humane Society this week: Top of the News Your email address will not be published. Required fields are marked * Community News Get our daily Pasadena newspaper in your email box. Free.Get all the latest Pasadena news, more than 10 fresh stories daily, 7 days a week at 7 a.m. More Cool Stuff Pasadena Will Allow Vaccinated People to Go Without Masks in Most Settings Starting on Tuesday Ace (A455113) is a 2-month-old domestic shorthair looking for a forever home. He was transferred to the Pasadena Humane Society from the ASPCA with a few of his kitten buddies in early May. He likes to play, eat, nap, and cuddle, and is looking for a new home and family to call his own.The adoption fee for cats is $75. All cats are spayed or neutered, microchipped, and vaccinated before being adopted.New adopters will receive a complimentary health-and-wellness exam from VCA Animal Hospitals, as well as a goody bag filled with information about how to care for your pet.View photos of adoptable pets at pasadenahumane.org. Adoption hours are 11 a.m. to 4 p.m. Sunday; 9 a.m. to 5 p.m. Tuesday through Friday; and 9 a.m. to 4 p.m. Saturday.Pets may not be available for adoption and cannot be held for potential adopters by phone calls or email. Herbeauty6 Trends To Look Like A Bombshell And 6 To Forget AboutHerbeautyHerbeautyHerbeautyThese Are 15 Great Style Tips From Asian WomenHerbeautyHerbeautyHerbeauty8 Easy Exotic Meals Anyone Can MakeHerbeautyHerbeautyHerbeautyThe Real Truth About The Pain Caused By MicrobladingHerbeautyHerbeautyHerbeautyWhat Is It That Actually Makes French Women So Admirable?HerbeautyHerbeautyHerbeautyGained Back All The Weight You Lost?HerbeautyHerbeauty Business News 3 recommendedShareShareTweetSharePin it Community News Pets of the Week at the Pasadena Humane Society Published on Tuesday, June 12, 2018 | 11:03 am Pasadena’s ‘626 Day’ Aims to Celebrate City, Boost Local Economy Home of the Week: Unique Pasadena Home Located on Madeline Drive, Pasadena
NewsLocal NewsO’Dea and Noonan in race to top pollBy admin – February 24, 2011 586 Facebook He commented: “We are a bit cautious because we polled very well right up until the last week in 2007, when we began to fade.“I’m positioned to get a seat, but Willie would need to lose a lot of votes not to top the poll”.According to O’Dea, it has been a hugely tough campaign.“The situation is not helped by the latest poll – Fianna Fail down two points – if that is reflected here, we will be lucky to hold on to one seat – take a poll of 14% – that is only 7% of a quota”.Kieran O’Donnell is confident of retaining his seat.And Peter Power is not even contemplating being left out of the equation.“I think both myself and Willie can be elected if Fianna Fail people vote strategically”.Sinn Fein’s Maurice Quinlivan, is of the belief the fourth seat is open.“With the exception of Michael Noonan, I don’t think there is a safe seat .He claimed that a lot of people in working class and lower income areas will be swapping their vote over from Fianna Fail to Sinn Féin.With Labour stabilised at 20%, Jan O’Sullivan remains upbeat.“We’ve had a very positive response, and there’s a very good chance of a second seat”.Quietly confident, Labour’s Joe Leddin said he is feeling very positive as he enters the home stretch.‘I’ve been getting emails, cards and text messages wishing me the best. People want to see new younger faces on the doorsteps”.Said Kevin Kiely: ‘I’ve been late into the campaign but I’m getting a very positive response. People are fed up with the mainstream parties”.Other candidates in the city are Cian Prendiville, (Socialist Party), Sheila Cahill, (Greens), Denis Riordan, (Independent), Conor O’Donoghue, (CSP), and Matt Larkin, (Independent).In the Limerick Constituency, Niall Collins, (Fianna Fail), Dan Neville, (Fine Gael) are seen as safe bets, with Patrick O’Donovan, (Fine Gael), John Dillon, (Independent), Bill O’Donnell, (Fine Gael) and James Heffernan, (Labour), seen as the strongest candidates for the third seat. Also in the running are Con Cremin, (Independent), Patrick O’Doherty, (Independent), Seamus Sherlock, (Independent) and Stephen Wall (Greens). Email THOUGH strongly favoured to overtake Willie O’Dea as poll topper in the Limerick City Constituency in Friday’s election, Michael Noonan told the Limerick Post, that both he and Fine Gael, were taking nothing for granted.O’Dea polled 19,082 first preferences in 2007, while Noonan recorded 7,507.Sign up for the weekly Limerick Post newsletter Sign Up WhatsApp Twitter Linkedin Advertisement Print Previous articleNoonan’s pledge for negative equity generationNext articleFriars’ generous gift remains unopened admin
Heart disease, stroke, sepsis, and cancer collectively cause the greatest number of deaths worldwide. They also have something else in common: All are associated with activated platelets, the cells that circulate in our bloodstreams and normally help form blood clots to stop bleeding and promote healing of injuries, but can also contribute to dangerous blood clots, tumors, and other problems. Several antiplatelet drugs have been developed to combat platelet-related conditions, but their effects are not easily reversible, and patients taking these drugs are at risk of uncontrolled bleeding if injured. Also, if these patients need to undergo surgery, they must stop their treatment for up to a week prior to the procedure, which raises their risk of developing clots.Now, a team of researchers at the Wyss Institute at Harvard University and several collaborating institutions has created a drug-free, reversible antiplatelet therapy that employs deactivated “decoy” platelets that could reduce the risk of blood clots and potentially prevent cancer metastasis as well. The research is reported in Science Translational Medicine.“The reversibility and immediate onset of action are major advantages of our platelet decoys,” said first author Anne-Laure Papa. “We envision them to be useful in hospital-based situations such as preventing clotting in high-risk patients just before they undergo surgery, or when given alongside chemotherapy to prevent existing tumors from spreading.”Papa was a postdoctoral fellow at the Wyss Institute working with the institute’s director, Donald Ingber, when the research was carried out and is now an assistant professor at George Washington University. Ingber is the Judah Folkman Professor of Vascular Biology at Harvard Medical School and the Vascular Biology Program at Boston Children’s Hospital, as well as professor of bioengineering at Harvard’s School of Engineering and Applied Sciences.Canceling clotsThe decoys are human platelets whose outer lipid membranes and innards have been removed in the lab by centrifugation and treatment with a detergent. Because they are essentially empty, the decoys are about a third the size of normal platelets, but their surfaces retain the majority of their adhesive proteins. They can still use these surface molecules to bind to other cells that naturally occur in the bloodstream, but are unable to activate the clotting process.When the decoys were perfused into a microfluidic, blood-vessel-mimicking channel and exposed to platelet-stimulating chemicals, they did not display normal clotting behavior. And when the researchers added decoys to normal human blood in the channel (one decoy for every five platelets), they found that the normal platelets’ ability to aggregate and bind to the channel’s walls was reduced.“The decoys, unlike normal intact platelets, are unable to bind to the vessel wall and likely hinder the normal platelets’ ability to bind as well,” Papa explained. “A way to imagine this would be that the decoys are fast-moving skaters skating along the wall of an ice rink, and their high speed prevents other skaters from getting to the wall, thus limiting them from slowing down and grabbing onto it.”Importantly, the scientists were able to rapidly reverse the decoys’ inhibition of normal platelet activity simply by adding fresh platelets to the channels. Administering platelets to patients intravenously is already a common procedure in hospitals, so a patient with decoy platelets who needed to quickly regain the ability to form blood clots because of an injury or surgery could be easily and rapidly treated. The decoys also could be created from platelets removed from the same patient, offering a form of personalized cellular therapy that would not trigger an immune reaction.After the channel experiments the researchers tested their decoys in rabbits and found that the same 1-to-5 ratio of decoys to normal platelets in their blood prevented them from developing clots after a blood vessel injury. Rabbits and humans have similar blood platelet counts and platelet sizes, so it is likely that the decoys would have the same effect in human patients.Thwarting tumorsIn addition to binding to one another and to blood vessel walls, platelets are known to bind to cancer cells, protecting them from the body’s immune system and thereby helping them form new metastatic tumors at distant sites. When the team perfused normal platelets and human breast cancer cells into their microfluidic channels, the cancer cells stuck to and started invading the walls of the channel, similar to the way they form new tumors. Adding decoys along with normal platelets almost completely prevented the platelets from helping the cancer cells invade the channel wall, suggesting they could prevent the formation of new tumors.To confirm this potential, the researchers injected mice with either human platelets or a combination of platelets and decoys, and then with human breast cancer cells. The team found that the mice that received the platelets plus decoys developed significantly smaller and fewer metastatic tumors than the ones that received platelets only. Though they have not yet been tested in humans, it is possible that one day these decoys could be infused into patients during chemotherapy to prevent existing tumors from spreading, or injected during cancer surgeries to stop released tumor cells from forming new tumors elsewhere in the body.Papa and her colleagues are continuing to work on this technology to ensure that the decoys can last in the bloodstream for enhanced effectiveness, and are studying whether they can be loaded with drugs to help deliver therapies directly to the sites of blood clots and tumors, or possibly even kill circulating tumor cells in the bloodstream.“In this study,” Ingber said, “we were able to create what is effectively a dominant-negative cellular therapy to prevent platelet activation–induced clotting and metastatic cascades. It’s another example of how seemingly unrelated diseases often have common contributing factors, such as inflammation, stress, or, in this case, activated platelets, and that we can develop new therapies for multiple disorders by targeting one of those key factors.”Additional authors of the paper include Amanda Jiang, Akiko Mammoto, and Tadanori Mammoto from Boston Children’s Hospital and Harvard Medical School; Netanel Korin, Anna Waterhouse, Emma Nash, Amanda Graveline, Andyna Vernet, and Abhishek Jain from the Wyss Institute; Michelle Chen and Roger Kamm from MIT; and Erin Langan and Matthew Gounis from the New England Center for Stroke Research at the University of Massachusetts.This research was supported by the Wyss Institute for Biologically Inspired Engineering at Harvard University, a Department of Defense Breast Cancer Breakthrough Award, and the National Cancer Institute.
… Great Human potential – GiannantonioGUYANA’S Green Machine have added another trump card to their arsenal with the introduction of an Argentinian scrum coach on Tuesday. Deiego Giannantonio was presented to the media and other rugby stakeholders during a simple ceremony at the Argentine Embassy in Georgetown yesterday, where it was announced that his stint with the unit would be just about two weeks.Education Minister Dr Rupert Roopnaraine (left) converses with National coach Lawrence Adonis, in the presence of GRFU Patron Kit Nascimento and Ambassador Luis Alberto Martino. Robbie Roberts, Peter Green and Avery Corbin are also part of the conversation. (Samuel Maughn photo)In that time, he will work exclusively with the national 15s team as they prepare to play the final against their hosts Mexico on October 1.Speaking through a translator Nicholas Frazer, the coach who arrived on Monday and begun work on Tuesday contended:“I’d like to give to you in this short time I have, some tools for this very important game against Mexico.”“In the short time that I have seen them, I believe that there is great human potential in the players as well as the staff, but I believe that they must work a lot more as a team. Technically, I think that they can still get better but I see them now as very good,”Meanwhile, Argentinian ambassador said, “This is a good example for future cooperation,” noting that the process on his end took three days and some assistance from the Argentine Rugby Association and Foreign Affairs Ministry.“He (Deiego) has been working for many years with the world of rugby, he himself was a senior member of the Pumas, the 15s national team in the 90s,”newly acquired scrum coach Deiego Giannantonio shares a moment with one of the embassy staff.The second of the three parties involved, the Guyana Olympic Association through executive member Charles Corbin, contended that the body jumped at the Idea of support for the sport.He noted that the GOA covered the airfare and accommodation for Mr Giannantonio and feels that more mixtures of cultures and tactics from coaches outside of Guyana are the way forward.National coach Lawrence Adonis feels, “He (Deiego) is really and truly helping us out in our weaker parts of the game, especially in the scrums, the malls, the wraps, lineouts and so on and even some of the structures we currently have.”“It is working well for us, and we would like to see if we can keep him a bit more or have himEducation Minister Dr Rupert Roopnaraine makes a comment during yesterday’s press briefing.back sometime,” continued Adonis.The third party in the agreement, the Government of Guyana, represented by Senior Minister of Education, Dr Rupert Roopnaraine, stated that sport makes for more rounded individuals.Others in attendance at the ceremony were Guyana Rugby Football Union (GRFU) Patron Kit Nascimento, president Peter Green, manager Robin Roberts, senior player Avery Corbin and Director of Sport Christopher JonesMeanwhile, the government also chipped in by providing $2M towards the team’s preparation for the RAN finals, with the funding expected to go towards getting the team further acclimatised to the Mexican altitude.Giannantonio will be a part of the team’s touring contingent to Mexico and from there, he will return to Argentina.